Glaucoma – if not treated may lead to Blindness - Tips for early detection

Increased intraocular pressure – condition called as Glaucoma is a serious condition. If left untreated, this pressure can impair vision by causing irreversible damage to the optic nerve and, eventually, blindness. It results in peripheral vision loss, and is a dangerous eye condition because it progresses without obvious symptoms. Because of this it is often referred to as "the sneak thief of sight."

Early detection, appropriate and ongoing treatment, and the availability of specialized low vision and vision rehabilitation services can help people with glaucoma live productive and satisfying lives. As early as age 35, a pressure check for glaucoma should be an essential part of your annual routine eye examination. A visual field test will detect peripheral vision loss.

Possible Signs of Glaucoma:

Most common type is Open-angle glaucoma and is slow to develop.

As it progresses, you may notice that your side, or peripheral, vision is failing, causing you to miss objects out of the side and corner of your eye.

If you are suddenly experiencing the following symptoms, you may have Closure - angle glaucoma and should seek immediate treatment:

Other symptoms are:

• Blurred vision


• Nausea


• Headaches


• Halos around bright lights

Please contact your nearest ophthalmologist (eye doctor) if you have any of the symptoms.

Dr. Shiva Murthy N

Director – Clinical research and Business development

Quartesian LLC

The Chennai glaucoma survey results – Available in Indian Journal of ophthalmology - Year : 2010 | Volume : 58 | Issue : 3 | Page : 243-245

Report generated after 3850 subjects participated in the study. Most important outcome of the study is, 15 aphakes and 23 pseudophakes (total 38) (0.99% of 3850 subjects) of the 406 persons who had undergone cataract surgery were diagnosed with glaucoma. It is understoond that risk of glaucoma is higher in Aphakes/pseudophakes as compared to the phakic population (Odds Ratio: 2.71, 95% CI: 1. 94, 3.38, p=0.001). 20% of aphakic and 4.3% of pseudophakic eyes detected with Blindness attributable to glaucoma.


More details found in the below link:

http://www.ijo.in/article.asp?issn=0301-4738;year=2010;volume=58;issue=3;spage=243;epage=245;aulast=George

Hope this information is useful and enjoy reading all the contents of the article…

With best wishes,

Dr. Shiva Murthy N

Director-Clinical Research and Business Development,

Quartesian CRO

Introduction on ‘Journal of Pharmacy and BioAllied Sciences' (JPBS)

I am pleased to introduce 'Journal of Pharmacy and BioAllied Sciences' (JPBS). This journal was launched from the year 2009. The policy of the journal is to publish innovative articles, reviews, mini-reviews, rapid communications, and notes, dealing with all branches of Pharmaceutical Sciences, Medicinal / Analytical Chemistry, Biotechnology, and Bioallied Sciences, related to the conception, design, production, characterization, and evaluation of drugs and their delivery systems in vitro and in vivo. The journal is interested to publish articles on: Pharmaceutics, Pharmacy Practice, Drug Regulatory Affairs, Pharmacology, Synthesis of Novel Medicinal Compounds, Analytical Sciences, Phytomedicine, Nanotechnology, Physical Pharmacy, Polymer Chemistry, and Microbiology, as applied to pharmaceutical, medical, and health sciences. The official website the journal is www.jpbsonline.org, and online submission of manuscripts can also be done at www.journalonweb.com/jpbs.




Hope this information is useful and enjoy reading all the issues…



With best wishes,



Dr. Shiva Murthy N

Director, Clinical Research and Business Development
Quartesian LLC

Seizure and Coma due to hyponatremia induced by Vincristine

Patient with stage 1 Wilms tumour, on Vincristine had hyponatremia, presented as generalized tonic clonic seizures and coma. Investigations suggested no localizing neurological signs located to differentiate other causes of seizure. Treatment- Patient intubated and mechanically ventilated. Patient treated with fluid restriction, hypertonic saline (3%) and other supportive care. Patient improved clinically over three days and extubated on the third day and shifted to the ward on the fifth day. Complete report is available in Indian J of Crical Care Medicie, Year : 2009 Volume : 13 Issue : 3 Page : 167—168. Hope it is interesting for you and read more on this. Click below link to view complete report.
http://www.ijccm.org/downloadpdf.asp?issn=0972-5229;year=2009;volume=13;issue=3;spage=167;epage=168;aulast=Nagappa;type=2
Dr. Shivamurthy Nanjundappa, MD (Pharmacology)

Rituximab a chimeric monoclonal antibody targets the CD20

Rituximab a chimeric monoclonal antibody targets the CD20 molecule, leading to depletion of B-lymphocytes through antibody-dependent and complement-mediated cytotoxicity as well as by promotion of apoptotic mechanisms. Rituximab has been used in non-Hodgkin type B-cell lymphoma for over a decade,but is now being studied in a number of autoimmune conditions.It is proposed to be useful for Multiple sclerosis also.

Tamsulosin and alfuzosin are comparable in acute urinary retention

Comparison of alfuzosin and tamsulosin in patients suffering from acute urinary retention caused by benign prostatic hyperplasia (BPH) showed that Both groups had similar results which were significantly superior than placebo. Three months, followup suggested that alfuzosin- or tamsulosin-treated patients showed a significant decrease in AUA score and PVRV; and a significant increase in PFR as compared to placebo. Tamsulosin is considred to have comparable therapeutic benifits as that of alfuzosin in all respects, except a small but significant side effect of retrograde ejaculation. Detailed report available in Indian Journal of Urology (Indian J Urol)
2009 October-December Volume 25 Issue 4.

Dr. Shivamurthy Nanjundappa, MD (Pharmacology)

Mobile No: +919677632414
Alternate Email ID: shivuindia@yahoo.com

Ciprofloxacine - Toxic epidermal necrolysis agranulocytosis

Ciprofloxacin rarely produces Serious adverse reactions (<0.6%). Two rare adverse effects of ciprofloxacin, viz. toxic epidermal necrolysis and agranulocytosis reported recently. One case of granulocytopenia, four of pancytopenia and fifteen of leucopenia worldwide have been reported.

If you want to know more, please read from below link.

http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2009;volume=63;issue=10;spage=461;epage=463;aulast=Upadya;type=0

Thanks and kind regards,

Dr. Shiva Murthy N