Patient with stage 1 Wilms tumour, on Vincristine had hyponatremia, presented as generalized tonic clonic seizures and coma. Investigations suggested no localizing neurological signs located to differentiate other causes of seizure. Treatment- Patient intubated and mechanically ventilated. Patient treated with fluid restriction, hypertonic saline (3%) and other supportive care. Patient improved clinically over three days and extubated on the third day and shifted to the ward on the fifth day. Complete report is available in Indian J of Crical Care Medicie, Year : 2009 Volume : 13 Issue : 3 Page : 167—168. Hope it is interesting for you and read more on this. Click below link to view complete report.
http://www.ijccm.org/downloadpdf.asp?issn=0972-5229;year=2009;volume=13;issue=3;spage=167;epage=168;aulast=Nagappa;type=2
Dr. Shivamurthy Nanjundappa, MD (Pharmacology)
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