Seizure and Coma due to hyponatremia induced by Vincristine

Patient with stage 1 Wilms tumour, on Vincristine had hyponatremia, presented as generalized tonic clonic seizures and coma. Investigations suggested no localizing neurological signs located to differentiate other causes of seizure. Treatment- Patient intubated and mechanically ventilated. Patient treated with fluid restriction, hypertonic saline (3%) and other supportive care. Patient improved clinically over three days and extubated on the third day and shifted to the ward on the fifth day. Complete report is available in Indian J of Crical Care Medicie, Year : 2009 Volume : 13 Issue : 3 Page : 167—168. Hope it is interesting for you and read more on this. Click below link to view complete report.
http://www.ijccm.org/downloadpdf.asp?issn=0972-5229;year=2009;volume=13;issue=3;spage=167;epage=168;aulast=Nagappa;type=2
Dr. Shivamurthy Nanjundappa, MD (Pharmacology)

Rituximab a chimeric monoclonal antibody targets the CD20

Rituximab a chimeric monoclonal antibody targets the CD20 molecule, leading to depletion of B-lymphocytes through antibody-dependent and complement-mediated cytotoxicity as well as by promotion of apoptotic mechanisms. Rituximab has been used in non-Hodgkin type B-cell lymphoma for over a decade,but is now being studied in a number of autoimmune conditions.It is proposed to be useful for Multiple sclerosis also.

Tamsulosin and alfuzosin are comparable in acute urinary retention

Comparison of alfuzosin and tamsulosin in patients suffering from acute urinary retention caused by benign prostatic hyperplasia (BPH) showed that Both groups had similar results which were significantly superior than placebo. Three months, followup suggested that alfuzosin- or tamsulosin-treated patients showed a significant decrease in AUA score and PVRV; and a significant increase in PFR as compared to placebo. Tamsulosin is considred to have comparable therapeutic benifits as that of alfuzosin in all respects, except a small but significant side effect of retrograde ejaculation. Detailed report available in Indian Journal of Urology (Indian J Urol)
2009 October-December Volume 25 Issue 4.

Dr. Shivamurthy Nanjundappa, MD (Pharmacology)

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